2026-04-17T19:27:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2140672025-12-05T12:22:29Zcom_2072_1057col_2072_478916col_2072_478917

Prognostic Value of D-dimer to Lymphocyte Ratio (DLR) in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients: A Validation Study in a National Cohort Oblitas, Crhistian Mario Demelo Rodríguez, Pablo Álvarez-Sala Walther, Luis Antonio Rubio Rivas, Manuel Navarro Romero, Francisco Giner Galvañ, Vicente Jorge Huerta, Lucía de Fonseca Aizpuru, Eva García García, Gema María Beato Pérez, José Luis Pesqueira Fontán, Paula María Artero Mora, Arturo Vargas Núñez, Juan Antonio Ramírez Perea, Nuria García Bruñén, José Miguel Roy Vallejo, Emilia Perales Fraile, Isabel Gil Sánchez, Ricardo López Castro, José Martínez González, Ángel Luis Díez García, Luis Felipe Aroza Espinar, Marina Casas Rojo, José Manuel Millán Núñez-Cortés, Jesús Malalties immunitàries COVID-19 Immunologic diseases COVID-19 Background: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: A total of 10,575 COVID-19 patients were included in this study. The mean age of participants was 66.9 (+/- 16) years, and 58.6% (6202 patients) of them were male. The overall mortality rate was 16.3% (n = 1726 patients). Intensive care unit admission was needed in 10.5% (n = 1106 patients), non-invasive mechanical ventilation was required in 8.8% (n = 923 patients), and orotracheal intubation was required in 7.5% (789 patients). DLR presented a c-statistic of 0.69 (95% CI, 0.68-0.71) for in-hospital mortality with an optimal cut-off above 1. Multivariate analysis showed an independent association for in-hospital mortality for DLR > 1 (adjusted OR 2.09, 95% CI 1.09-4.04; p = 0.03); in the same way, survival analysis showed a higher mortality risk for DLR > 1 (HR 2.24; 95% CI 2.03-2.47; p < 0.01). Further, no other laboratory indices showed an independent association for mortality in multivariate analysis. Conclusions: This study confirmed the usefulness of DLR as a prognostic biomarker for mortality associated with SARS-CoV-2 infection, being an accessible, cost-effective, and easy-to-use biomarker in daily clinical practice. 2024-07-01T15:03:48Z 2024-07-01T15:03:48Z 2024-02-22 2024-06-14T09:30:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1999-4915 https://hdl.handle.net/2445/214067 38543700 eng Reproducció del document publicat a: https://doi.org/10.3390/v16030335 Viruses, 2024, vol. 16, num. 3 https://doi.org/10.3390/v16030335 cc by (c) Oblitas, Crhistian Mario et al, 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess 10 p. application/pdf MDPI AG Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))