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Effect of Fish Oil Parenteral Emulsion Supplementation on Inflammatory Parameters after Esophagectomy Suárez Lledó, Ana Llop Talaveron, Josep M. Leiva Badosa, Elisabet Farran Teixido, Leandre Miró Martín, Mónica Bas Minguet, Jordi Navarro Velázquez, Sergio Creus Costas, Gloria Virgili Casas, Nuria Fernández Álvarez, Mónica Badía Tahull, María B. Suplements nutritius Emulsions Dietary supplements Emulsions (Background) Esophagectomy (EPG) presents high morbidity and mortality. Omega-3 fatty acids (omega-3FA) are a pharmaconutrient with benefits for postoperative morbidity. Studies of omega-3FA administered parenterally after esophagectomy are scarce. This study proposes to investigate the effect of combining fish oil lipid emulsions (LE) administered parenterally with enteral nutrition support. (Methods) Randomization was 1:1:1 in three groups: Group A received a LE mixture of 0.4 g/kg/day of fish oil and 0.4 g/kg/day of LCT/MCT 50:50, Group B received 0.8 g/kg/day of fish oil LE, and Group C received 0.8 g/kg/day of LCT/MCT 50:50. Variables were measured at recruitment time and day +1, +3, and +5. Inflammatory variables studied were Interlukin-6, C-reactive protein (CRP), tumoral necrosis factor-alpha (TNF-alpha), IL-10, IL-8 and CD25s. Safety, nutritional parameters and complications were analyzed. (Results) Administration of omega-3LE in the immediate postoperative period did not modulate the earlier inflammatory response. Statistically significant differences were found in IL-6 and CRP overall temporal evolution but were not found when studying the type of LE administered or in patients needing critical care. Administration of omega-3 resulted in safe and improved hypertriglyceridemia, depending on the dose. (Conclusions) omega-3FA has no impact on the early inflammatory postoperative response assessed for a short period but was safe. More studies for longer periods are needed. 2024-02-23T16:03:51Z 2024-02-23T16:03:51Z 2023-12-21 2024-01-29T10:22:44Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/nu16010040 Nutrients, 2023, vol. 16, num. 1, p. 40 https://doi.org/10.3390/nu16010040 cc by (c) Suárez Lledó, Ana et al, 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI AG Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))