2026-04-17T02:36:40Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2044002025-12-05T12:07:16Zcom_2072_1057col_2072_478916col_2072_478917

Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections Ruiz Cáceres, Inmaculada Hermida Romero, Teresa Guerra Merino, Isabel Portu Zapirain, Joseba Pérez Mies, Belén Sánchez Conde, Matilde Alonso Riaño, Marina Rubio Campillo, Rafael Fortés Alen, Jose Vidal González, Ánxela Salas Antón, Clara Múñez, Elena Sánchez Sánchez, Rafael Corona Mata, Diana Aldecoa Ansorregui, Iban Miró Meda, José M. (José María), 1956- Beloqui Pérez de Obanos, Raquel Ibero, Carlos Gómez Román, Javier Fariñas, María Carmen Tabuyo Bello, Teresa Alava, Enrique de Cisneros, José Miguel Matias-Guiu, Xavier, 1958- Rivero, Antonio NecroCOVID Study Group COVID-19 Fisiologia patològica COVID-19 Pathological physiology IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. MethodsThis was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. ResultsMedian (IQR) age was 70 (range 63.75-74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p = 0.036 and p = 0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. ConclusionOur study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology. 2023-12-11T09:53:16Z 2023-12-11T09:53:16Z 2023-07-04 2023-08-17T13:02:29Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3389/fmed.2023.1151843 Frontiers in Medicine, 2023, vol. 10 https://doi.org/10.3389/fmed.2023.1151843 cc by (c) Ruiz Cáceres, Inmaculada et al., 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Frontiers Media SA Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))