2026-04-13T07:31:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2044002025-12-05T12:07:16Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Ruiz Cáceres, Inmaculada author Hermida Romero, Teresa author Guerra Merino, Isabel author Portu Zapirain, Joseba author Pérez Mies, Belén author Sánchez Conde, Matilde author Alonso Riaño, Marina author Rubio Campillo, Rafael author Fortés Alen, Jose author Vidal González, Ánxela author Salas Antón, Clara author Múñez, Elena author Sánchez Sánchez, Rafael author Corona Mata, Diana author Aldecoa Ansorregui, Iban author Miró Meda, José M. (José María), 1956- author Beloqui Pérez de Obanos, Raquel author Ibero, Carlos author Gómez Román, Javier author Fariñas, María Carmen author Tabuyo Bello, Teresa author Alava, Enrique de author Cisneros, José Miguel author Matias-Guiu, Xavier, 1958- author Rivero, Antonio author NecroCOVID Study Group author 2023-12-11T09:53:16Z 2023-12-11T09:53:16Z 2023-07-04 2023-08-17T13:02:29Z IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. MethodsThis was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. ResultsMedian (IQR) age was 70 (range 63.75-74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p = 0.036 and p = 0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. ConclusionOur study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology. COVID-19 Fisiologia patològica COVID-19 Pathological physiology Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections