2026-04-13T11:56:44Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2027252025-12-05T12:12:19Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT author Gómez Lara, Josep author Gracida Blancas, Montserrat author Rivero, Fernando author Gutiérrez Barrios, Alejandro author Muntané Carol, Guillem author Romaguera, Rafael author Fuentes, Lara author Marcano, Ana Lucrecia author Roura i Ferrer, Gerard author Ferreiro Guitiérrez, José Luis author Teruel, Luis author Brugaletta, Salvatore author Alfonso, Fernando author Comín Colet, Josep author Gómez Hospital, Joan Antoni 2023-10-09T12:16:00Z2023-10-09T12:16:00Z2023-06-222023-09-04T12:47:29Z BACKGROUND: ST-segment-elevation myocardial infarction complicated with no reflow after primary percutaneous coronary intervention is associated with adverse outcomes. Although several hyperemic drugs have been shown to improve the Thrombolysis in Myocardial Infarction flow, optimal treatment of no reflow remains unsettled. Saline infusion at 20 mL/min via a dedicated microcatheter causes (flow-mediated) hyperemia. The objective is to compare the efficacy of pharmacologic versus flow-mediated hyperemia in patients with ST-segment-elevation myocardial infarction complicated with no reflow. METHODS AND RESULTS: In the RAIN-FLOW (Treatment of Slow-Flow After Primary Percutaneous Coronary Intervention With Flow-Mediated Hyperemia) study, 67 patients with ST-segment-elevation myocardial infarction and no reflow were randomized to receive either pharmacologic-mediated hyperemia with intracoronary adenosine or nitroprusside (n=30) versus flow-mediated hyperemia (n=37). The angiographic corrected Thrombolysis in Myocardial Infarction frame count and the minimal microcirculatory resistance, as assessed with intracoronary pressure-thermistor wire, dedicated microcatheter, and thermodilution techniques, were compared after study interventions. Both Thrombolysis in Myocardial Infarction frame count(40.2 +/- 23.1 versus 39.2 +/- 20.7; P=0.858) and minimal microcirculatory resistance (753.6 +/- 661.5 versus 993.3 +/- 740.8 Wood units; P=0.174) were similar between groups. Thrombolysis in Myocardial Infarction 3 flow was observed in 26.7% versus 27.0% (P=0.899). Flow-mediated hyperemia showed 2 different thermodilution patterns during saline infusion indicative of the severity of the no reflow phenomenon. In-hospital death and nonfatal heart failure were observed in 10.4% and 26.9%, respectively. CONCLUSIONS: Both treatments showed similar (and limited) efficacy restoring coronary flow. Flow-mediated hyperemia with thermodilution pattern assessment allowed the simultaneous characterization of the no reflow degree and response to hyperemia. No reflow was associated with a high rate of adverse outcomes. Further research is warranted to prevent and to treat no reflow in patients with ST-segment-elevation myocardial infarction. cc by-nc (c) Gómez Lara, Josep et al., 2023 http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Angiografia Insuficiència cardíaca Fisiologia Angiography Heart failure Circulation of the blood Treatment of Slow‐Flow After Primary Percutaneous Coronary Intervention With Flow‐Mediated Hyperemia: The Randomized RAIN‐FLOW Study info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion