2026-04-17T03:46:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2012992025-12-05T09:43:13Zcom_2072_1057col_2072_478778col_2072_478917

Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review Castro Quintas, Águeda Palma-Gudiel, Helena San Martín-Gonzalez, Nerea Caso, Javier R. Leza, Juan C. Fañanás Saura, Lourdes Estrès (Psicologia) Ritmes circadiaris Infància Adolescència Resposta immunitària Stress (Psychology) Circadian rhythms Childhood Adolescence Immune response Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor. 2023-07-28T08:14:54Z 2023-07-28T08:14:54Z 2023-07-21 2023-07-28T08:14:54Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1016/j.yfrne.2023.101083 Frontiers in Neuroendocrinology, 2023, vol. 71, num. 101083, p. 1-16 https://doi.org/10.1016/j.yfrne.2023.101083 cc-by-nc-nd (c) Castro-Quintas, Águeda et al., 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Elsevier Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)