2026-04-19T19:21:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/2012992025-12-05T09:43:13Zcom_2072_1057col_2072_478778col_2072_478917

00925njm 22002777a 4500 dc Castro Quintas, Águeda author Palma-Gudiel, Helena author San Martín-Gonzalez, Nerea author Caso, Javier R. author Leza, Juan C. author Fañanás Saura, Lourdes author 2023-07-28T08:14:54Z 2023-07-28T08:14:54Z 2023-07-21 2023-07-28T08:14:54Z Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor. Estrès (Psicologia) Ritmes circadiaris Infància Adolescència Resposta immunitària Stress (Psychology) Circadian rhythms Childhood Adolescence Immune response Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review