2026-04-13T01:33:17Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/2011472025-12-04T19:31:52Zcom_2072_1057col_2072_478908col_2072_478917
RECERCAT author González, Laura author Domingo Muelas, Ana author Duart Abadia, Pere author Núñez, Marc author Mikolcevic, Petra author Llonch, Elisabet author Cubillos Rojas, Mónica author Cánovas Bilbao, Begoña author Forrow, Stephen M. A. author Morante Redolat, José Manuel author Fariñas, Isabel author Nebreda, Àngel R. 2023-07-25T11:32:28Z2023-07-25T11:32:28Z2023-02-142023-07-14T10:21:08Z In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche provide neurons for olfactory circuits and can be found at different depths of quiescence, but very little is known on how their quiescence-to-activation transition is controlled. Here, we identify the atypical cyclin-dependent kinase (CDK) activator RingoA as a regulator of this process. We show that the expression of RingoA increases the levels of CDK activity and facilitates cell cycle entry of a subset of NSCs that divide slowly. Accordingly, RingoA-deficient mice exhibit reduced olfactory neurogenesis with an accumulation of quiescent NSCs. Our results indicate that RingoA plays an important role in setting the threshold of CDK activity required for adult NSCs to exit quiescence and may represent a dormancy regulator in adult mammalian tissues.© 2023 The Author(s). cc by-nc-nd (c) González, Laura et al, 2023 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Neurociències Biologia molecular Neurosciences Molecular biology The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion