2026-04-17T01:23:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1990022025-12-05T09:35:12Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Estévez Povedano, Raúl author Elorza Vidal, Xabier author Gaitán-Peñas, Héctor author Pérez Rius, Carla author Armand-Ugón, Mercedes author Alonso Gardón, Marta author Xicoy Espaulella, Efren author Sirisi Dolcet, Sònia author Arnedo Llena, Tanit author Capdevila Nortes, Xavier author López Hernández, Tania author Montolio, Marisol author Duarri, Anna author Teijido, Oscar author Barrallo Gimeno, Alejandro author Palacín Prieto, Manuel author Nunes Martínez, Virginia author 2023-06-08T16:06:36Z 2023-06-08T16:06:36Z 2018-01-01 2023-06-08T16:06:36Z Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy characterized by dysfunction of the role of glial cells in controlling brain fluid and ion homeostasis. Patients affected by MLC present macrocephaly, cysts and white matter vacuolation, which lead to motor and cognitive impairments. To date, there is no treatment for MLC, only supportive care. MLC is caused by mutations in the MLC1 and GLIALCAM genes. MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family. Both proteins form a complex with an as-yet-unknown function that is expressed mainly in the astrocytes surrounding the blood-brain barrier and in Bergmann glia. GlialCAM also acts as an auxiliary subunit of the chloride channel ClC-2, thus regulating its localization at cell-cell junctions and modifying its functional properties by affecting the common gate of ClC-2. Recent studies in Mlc1-,GlialCAM-and Clcn2-knockout mice or Mlc1- knockout zebrafish have provided fresh insight into the pathophysiology of MLC and further details about the molecular interactions between these three proteins. Additional studies have shown that GlialCAM/MLC1 also regulates other ion channels (TRPV4, VRAC) or transporters (Na+/K+-ATPase) in a not-understood manner. Furthermore, it has been shown that GlialCAM/ MLC1 may influence signal transduction mechanisms, thereby affecting other proteins not related with transport such as the EGFreceptor. Here, we offer a personal biochemical retrospective of the work that has been performed to gain knowledge of the pathophysiology of MLC, and we discuss future strategies that may be used to identify therapeutic solutions for MLC patients. Animals Cervell Quistos Cicle cel·lular Animals Brain Cysts (Pathology) Cell cycle Megalencephalic leukoencephalopathy with subcortical cysts: a personal biochemical retrospective