2026-04-17T14:16:34Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1986802025-12-04T19:09:22Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921
RECERCAT
author
Alé Chilet, Aníbal Raimundo
author
Bernal Morales, Carolina
author
Barraso, Marina
author
Hernández, Teresa
author
Oliva, Cristian
author
Vinagre, Irene
author
Ortega Martínez de Victoria, Emilio
author
Figueras Roca, Marc
author
Sala Puigdollers, Anna
author
Esquinas López, Cristina
author
Giménez, Marga
author
Esmatjes Mompó, Enric
author
Adán Civera, Alfredo
author
Zarranz Ventura, Javier
2023-05-30T16:07:39Z2023-05-30T16:07:39Z2021-12-302023-05-30T16:07:39Z
The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications. A total of 425 individuals (1 eye/1 patient) were included. Reduced VD and FAZc were associated with greater categories of GFR (p = 0.002, p = 0.04), ACR (p = 0.003, p = 0.005) and KDIGO risk prognosis classifications (p = 0.002, p = 0.005). FAZc was significantly reduced in greater KDIGO prognosis risk categories (low risk vs. moderate risk, 0.65 ± 0.09 vs. 0.60 ± 0.07, p < 0.05). VD and FAZc presented the best diagnostic performance in ROCs. In conclusion, OCTA parameters, such as VD and FAZc, are able to detect different GFR, ACR, and KDIGO categories in T1DM patients and controls in a non-invasive, objective quantitative way. FAZc is able to discriminate within T1DM patients those with greater DKD categories and greater risk of DKD progression.
cc-by (c) Alé Chilet, Aníbal et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Diabetis
Nefropaties diabètiques
Malalties del ronyó
Moviments oculars
Tomografia de coherència òptica
Diabetes
Diabetic nephropathies
Kidney diseases
Eye movements
Optical coherence tomography
Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion