2026-04-14T02:11:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1986802025-12-04T19:09:22Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Alé Chilet, Aníbal Raimundo author Bernal Morales, Carolina author Barraso, Marina author Hernández, Teresa author Oliva, Cristian author Vinagre, Irene author Ortega Martínez de Victoria, Emilio author Figueras Roca, Marc author Sala Puigdollers, Anna author Esquinas López, Cristina author Giménez, Marga author Esmatjes Mompó, Enric author Adán Civera, Alfredo author Zarranz Ventura, Javier author 2023-05-30T16:07:39Z 2023-05-30T16:07:39Z 2021-12-30 2023-05-30T16:07:39Z The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications. A total of 425 individuals (1 eye/1 patient) were included. Reduced VD and FAZc were associated with greater categories of GFR (p = 0.002, p = 0.04), ACR (p = 0.003, p = 0.005) and KDIGO risk prognosis classifications (p = 0.002, p = 0.005). FAZc was significantly reduced in greater KDIGO prognosis risk categories (low risk vs. moderate risk, 0.65 ± 0.09 vs. 0.60 ± 0.07, p < 0.05). VD and FAZc presented the best diagnostic performance in ROCs. In conclusion, OCTA parameters, such as VD and FAZc, are able to detect different GFR, ACR, and KDIGO categories in T1DM patients and controls in a non-invasive, objective quantitative way. FAZc is able to discriminate within T1DM patients those with greater DKD categories and greater risk of DKD progression. Diabetis Nefropaties diabètiques Malalties del ronyó Moviments oculars Tomografia de coherència òptica Diabetes Diabetic nephropathies Kidney diseases Eye movements Optical coherence tomography Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.