2026-04-18T00:24:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1976652025-12-05T12:38:46Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Brunet, Aina author Milara, Javier author Frías, Soledad author Cortijo, Julio author Armengot, Miguel author 2023-05-08T11:16:15Z 2023-05-08T11:16:15Z 2023-02-09 2023-04-14T10:55:02Z Background: Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients' QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance (p = 0.04) and the endoscopic polyp score (p = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia (p = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP. Malalties otorrinolaringològiques Qualitat de vida Otorhinolaryngologic diseases Quality of life Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps