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Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies Pena-Rodríguez, Eloy Lajarin Reinares, Maria Mata i Ventosa, Aida Perez Torras, Sandra Fernández Campos, Francisco Pell Nanopartícules Skin Nanoparticles Follicular targeting has gained more attention in recent decades, due to the possibility of obtaining a depot effect in topical administration and its potential as a tool to treat hair follicle-related diseases. Lipid core ethyl cellulose lipomers were developed and optimized, following which characterization of their physicochemical properties was carried out. Dexamethasone was encapsulated in the lipomers (size, 115 nm; polydispersity, 0.24; zeta-potential (Z-potential), +30 mV) and their in vitro release profiles against dexamethasone in solution were investigated by vertical diffusion Franz cells. The skin biodistribution of the fluorescent-loaded lipomers was observed using confocal microscopy, demonstrating the accumulation of both lipomers and fluorochromes in the hair follicles of pig skin. To confirm this fact, immunofluorescence of the dexamethasone-loaded lipomers was carried out in pig hair follicles. The anti-inflammatory (via TNFα) efficacy of the dexamethasone-loaded lipomers was demonstrated in vitro in an HEK001 human keratinocytes cell culture and the in vitro cytotoxicity of the nanoformulation was investigated. 2023-04-13T08:52:26Z 2023-04-13T08:52:26Z 2021-04-11 2023-04-13T08:52:26Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1999-4923 https://hdl.handle.net/2445/196724 717670 eng Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13040533 Pharmaceutics, 2021, vol. 13, num. 4, p. 533 https://doi.org/10.3390/pharmaceutics13040533 cc-by (c) Pena Rodriguez, Eloy et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 19 p. application/pdf MDPI Articles publicats en revistes (Bioquímica i Biomedicina Molecular)