2026-04-13T05:03:24Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1967242025-12-04T21:13:28Zcom_2072_1057col_2072_478781col_2072_478917

00925njm 22002777a 4500 dc Pena-Rodríguez, Eloy author Lajarin Reinares, Maria author Mata i Ventosa, Aida author Perez Torras, Sandra author Fernández Campos, Francisco author 2023-04-13T08:52:26Z 2023-04-13T08:52:26Z 2021-04-11 2023-04-13T08:52:26Z Follicular targeting has gained more attention in recent decades, due to the possibility of obtaining a depot effect in topical administration and its potential as a tool to treat hair follicle-related diseases. Lipid core ethyl cellulose lipomers were developed and optimized, following which characterization of their physicochemical properties was carried out. Dexamethasone was encapsulated in the lipomers (size, 115 nm; polydispersity, 0.24; zeta-potential (Z-potential), +30 mV) and their in vitro release profiles against dexamethasone in solution were investigated by vertical diffusion Franz cells. The skin biodistribution of the fluorescent-loaded lipomers was observed using confocal microscopy, demonstrating the accumulation of both lipomers and fluorochromes in the hair follicles of pig skin. To confirm this fact, immunofluorescence of the dexamethasone-loaded lipomers was carried out in pig hair follicles. The anti-inflammatory (via TNFα) efficacy of the dexamethasone-loaded lipomers was demonstrated in vitro in an HEK001 human keratinocytes cell culture and the in vitro cytotoxicity of the nanoformulation was investigated. Pell Nanopartícules Skin Nanoparticles Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies