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Defining clinical characteristics of emotion dysregulation in bipolar disorder: A systematic review and meta-analysis De Prisco, Michele Oliva, Vincenzo Fico, Giovanna Fornaro, Michele De Bartolomeis, Andrea Serretti, Alessandro Vieta i Pascual, Eduard, 1963- Murru, Andrea Trastorn bipolar Trastorns afectius Emocions Metaanàlisi Adaptació (Psicologia) Manic-depressive illness Affective disorders Emotions Meta-analysis Adaptability (Psychology) Emotion dysregulation (ED) is characterized by rigid and frequent use of maladaptive emotion regulation (ER) strategies. Conceptualized as a transdiagnostic feature, ED may occur in both clinical and non-clinical populations, including people diagnosed with bipolar disorder (BD) and their first-degree relatives (FDRs), though expected to manifest with differential clinical features. To this end, we conducted a systematic review and meta-analysis of the literature comparing people with BD to healthy controls (HCs) or FDRs, from inception up to November 25, 2021, across major databases. Random-effects meta-analyses considered twenty-eight studies assessing ER/ED with a validated scale. Patients with BD differed from HCs in adopting more maladaptive ER strategies, such as rumination, risk-taking behaviors, negative focus, and less adaptive ones. Unaffected FDRs differed from people with BD, yet to a lower extent, suggesting that ED may span a continuum. ED in BD should be widely explored to better understand its course and management, with specific interventions aimed at reducing its burden on both high-risk and full-threshold populations. 2023-03-23T15:17:48Z 2023-03-23T15:17:48Z 2022-11-01 2023-03-23T15:17:48Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0149-7634 https://hdl.handle.net/2445/195849 726297 36243194 eng Reproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2022.104914 Neuroscience and Biobehavioral Reviews, 2022, vol. 142, p. 104914 https://doi.org/10.1016/j.neubiorev.2022.104914 cc-by-nc-nd (c) De Prisco, Michele et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess 17 p. application/pdf Elsevier Articles publicats en revistes (Medicina)