2026-04-17T06:55:04Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1957472025-11-20T15:54:20Zcom_2072_1057col_2072_478798col_2072_478917
RECERCAT
author
Rischin, Danny
author
Harrington, Kevin J.
author
Greil, Richard
author
Soulières, Denis
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Tahara, Makoto
author
Castro, Gilberto de
author
Psyrri, Amanda
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Braña, Irene
author
Neupane, Prakash
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Bratland, Åse
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Fuereder, Thorsten
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Hughes, Brett G.M.
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Mesía Nin, Ricard
author
Ngamphaiboon, Nuttapong
author
Rordorf, Tamara
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Ishak, Wan Zamaniah Wan
author
Hong, Ruey-Long
author
González Mendoza, René
author
Jia, Liyi
author
Chirovsky, Diana
author
Norquist, Josephine
author
Jin, Fan
author
Burtness, Barbara
2023-03-21T18:11:11Z2023-03-21T18:11:11Z2022-052023-03-21T18:11:11Z
Objectives: To assess health-related quality of life (HRQoL) with first-line pembrolizumab, pembrolizumab-chemotherapy, or cetuximab-chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) in the phase 3 KEYNOTE-048 trial (NCT02358031). Materials and methods: HRQoL was measured using the European Organisation for Research and Treatment of Cancer 30-question quality-of-life (EORTC QLQ-C30), the EORTC 35-question quality-of-life head and neck cancer-specific module (EORTC QLQ-H&N35), and the EuroQol 5-dimension 3-level instruments (EQ-5D-3L). Secondary endpoints included mean change from baseline in EORTC QLQ-C30 global health status/quality of life (GHS/QoL) at week 15 and time to deterioration (TTD) in EORTC QLQ-C30 GHS/QoL and EORTC QLQ-H&N35 pain and swallowing. Results: Of 882 enrolled participants, 844 received ≥ 1 dose of study treatment and completed ≥ 1 HRQoL assessment; adherence was ≥ 79% at week 15 across treatment groups. At week 15, EORTC QLQ-C30 GHS/QoL scores remained stable; no clinically meaningful between-group differences were observed (least squares mean difference, pembrolizumab vs cetuximab-chemotherapy, 0.24; 95% CI, -3.34 to 3.82; pembrolizumab-chemotherapy vs cetuximab-chemotherapy, 0.40; 95% CI, -3.46 to 4.26). Median TTD in EORTC QLQ-C30 GHS/QoL and EORTC QLQ-H&N35 pain and swallowing scores was not reached over 51 weeks across groups, showing stable HRQoL. TTD was similar between groups for EORTC QLQ-C30 GHS/QoL (pembrolizumab vs cetuximab-chemotherapy: HR, 1.38; 95% CI, 0.95-2.00; pembrolizumab-chemotherapy vs cetuximab-chemotherapy: HR, 1.37; 95% CI, 0.94-2.00), as was TTD in EORTC QLQ-H&N35 pain and swallowing scores. Conclusions: Pembrolizumab monotherapy and pembrolizumab-chemotherapy extended OS while maintaining HRQoL, further supporting first-line use for R/M HNSCC.
cc-by-nc-nd (c) Elsevier Ltd, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Anticossos monoclonals
Quimioteràpia
Malalties cròniques
Càncer de coll
Càncer de cap
Monoclonal antibodies
Chemotherapy
Chronic diseases
Neck cancer
Head cancer
Pembrolizumab alone or with chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: health-related quality-of-life results from KEYNOTE-048
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion