2026-04-17T00:57:30Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1952102025-12-05T14:12:51Zcom_2072_1057col_2072_478815col_2072_478917
RECERCAT
author
Allaw, Mohamad
author
Manconi, Maria
author
Carboni, Pierluigi
author
Bacchetta, Gianluigi
author
Escribano Ferrer, Elvira
author
Peris, José Esteban
author
Nacher, Amparo
author
Diez-Sales, Octavio
author
Manca, Maria Letizia
2023-03-14T12:21:28Z2023-03-14T12:21:28Z2021-10-192023-03-14T12:21:28Z
Pistacia lentiscus L. is a sclerophyllous shrub capable of growing under harsh climatic conditions especially in the Mediterranean Basin. Different products can be obtained from this plant, such as essential oil, mastic gum or even fixed oil. The last is well known for its flavor which is mainly exploited in the food industry. Additionally, it has been traditionally used in the treatment of skin diseases, but, at the moment, any suitable formulation for skin delivery has been formulated and its biological effects was not deeply confirmed. Given that, in the present study, the lentisk oil has been formulated in liposomes at different concentrations (10, 20, 30 mg/ml) and their physicochemical, technological and main biological properties have been evaluated. Vesicles were prepared by using natural soy lecithin and a green and organic solvent free method, thus obtaining spherical, small (~ 118 nm), homogeneously dispersed (0.27) and highly negatively charged (~ -62 mV) vesicles. The used amount of oil loaded in liposomes (10, 20, 30 mg/ml) modulated the penetration ability of vesicles in the skin, favoring the deposition of the payload in the deeper strata. The loading in the vesicles potentiated the ability of oil to counteract the damaging effects caused by hydrogen peroxide in keratinocytes and fibroblasts and facilitate their migration in a cell monolayer lesion. Overall findings suggested that the incorporation of lentisk oil in liposomes made from soy lecithin can be an alternative and natural approach to exploit it in pharmaceutical ad cosmetical applications and manufacturing natural products suitable for the treatment of skin lesions. Keywords: Keratinocytes & fibroblasts; Liposomes; Pistacia lentiscus; Scratch assay; Skin permeation studies, confocal microscopy; Wound healing.
cc by-nc-nd (c) Mohamad Allaw, et al., 2021 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
Liposomes
Olis essencials
Absorció cutània
Liposomes
Essences and essential oils
Skin absorption
Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion