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Esrrb Regulates Specific Feed-Forward Loops to Transit From Pluripotency Into Early Stages of Differentiation Mazloom, Amin R. Xu, Huilei Reig-Palou, Jaume Vasileva, Ana Román, Angel-Carlos Mulero-Navarro, Sonia Lemischka, Ihor R. Sevilla, Ana Micro RNAs Compostos bioactius vegetals MicroRNAs Plant bioactive compounds Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to play a relevant role in cellular differentiation, the role of miRNAs integrated into gene regulatory networks and its dynamic changes during these early stages of embryonic stem cell (ESC) differentiation remain elusive. Here we describe the dynamic transcriptional regulatory circuitry of stem cells that incorporate protein-coding and miRNA genes based on miRNA array expression and quantitative sequencing of short transcripts upon the downregulation of the Estrogen Related Receptor Beta (Esrrb). The data reveals how Esrrb, a key stem cell transcription factor, regulates a specific stem cell miRNA expression program and integrates dynamic changes of feed-forward loops contributing to the early stages of cell differentiation upon its downregulation. Together these findings provide new insights on the architecture of the combined transcriptional post-transcriptional regulatory network in embryonic stem cells. 2023-03-03T10:29:09Z 2023-03-03T10:29:09Z 2022-05-16 2023-03-03T10:29:09Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2296-634X https://hdl.handle.net/2445/194585 723671 eng Reproducció del document publicat a: https://doi.org/10.3389/fcell.2022.820255 Frontiers In Cell And Developmental Biology, 2022, vol. 10 https://doi.org/10.3389/fcell.2022.820255 cc-by (c) Mazloom, Amin R. et al., 2022 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 13 p. application/pdf Frontiers Media Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)