2026-04-13T03:59:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1943822025-12-05T09:54:54Zcom_2072_1057col_2072_478917col_2072_478920

00925njm 22002777a 4500 dc Malagelada Prats, Carolina author Bendezú, Álvaro author Seguí Mesquida, Santi author Vitrià i Marca, Jordi author Merino, Xavier author Nieto, Adoración author Sihuay, Denisse author Accarino Garaventa, Anna Maria author Molero, Xavier author Azpiroz, Fernando author 2023-03-01T09:35:56Z 2023-03-01T09:35:56Z 2020-05-31 2023-03-01T09:35:56Z Background Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Cystic fibrosis transmembrane conductance regulator is extensively expressed in the intestine and has an important role in the regulation of the viscosity and pH of gut secretions. Several studies have reported a delay in small bowel and colonic transit times in patients with CF which have been attributed to the secretory dysfunction. Our aim was to determine whether intestinal contractility is affected in these patients. Methods Consecutive patients with CF referred to our institution between 2014 and 2017 (n = 16) were prospectively investigated using automated non-invasive techniques for morpho-functional evaluation of the gut developed in our laboratory. On separate days, intraluminal images of the gut were obtained by capsule endoscopy and external images by abdominal MRI. Analysis of images (endoluminal and external) was performed with original, previously validated programs based on computer vision and machine learning techniques and compared with age- and sex-matched controls. Key Results Patients with CF exhibited important reduction in contractile activity and increased retention of static turbid luminal content in the small bowel by endoluminal image analysis. Morpho-volumetric analysis of MRI images found increased ileo-colonic volumes in CF. Significant correlations between abnormalities detected by intraluminal and external imaging techniques were found. The presence and severity of digestive symptoms were not related to abnormal gut function. Conclusion and Inferences Impaired transit and pooling of gut contents in patients with CF is associated with impaired intestinal motility. Càpsula endoscòpica Fibrosi quística Imatges per ressonància magnètica Visió per ordinador Aprenentatge automàtic Capsule endoscopy Cystic fibrosis Magnetic resonance imaging Computer vision Machine learning Morphological and functional evaluation of the gut in cystic fibrosis