2026-04-13T13:35:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1943342025-12-04T22:32:42Zcom_2072_1057col_2072_478917col_2072_478931

00925njm 22002777a 4500 dc Castells Sánchez, Alba author Roig-Coll, Francesca author Dacosta-Aguayo, Rosalia author Lamonja-Vicente, Noemí author Torán Monserrat, Pere author Pera, Guillem author García Molina, Alberto author Tormos, José María author Montero Alía, Pilar author Heras Tebar, Antonio author Soriano Raya, Juan José author Cáceres, Cynthia author Domènech, Sira author Via i García, Marc author Erickson, Kirk I. author Mataró Serrat, Maria author 2023-02-28T18:14:32Z 2023-02-28T18:14:32Z 2022-04-20 2023-02-28T18:14:32Z Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week (5 days per week-45 min per day) multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise (AE), computerized cognitive training (CCT) and a combined (COMB) groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited (62% female; age = 58.38 ± 5.47). In this study we report intervention-related changes in plasma biomarkers (BDNF, TNF-α, HGF, ICAM-1, SDF1-α) and structural-MRI (brain volume) and how they related to changes in physical activity and individual variables (age and sex) and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions. Neuropsicologia Exercici Envelliment Neuropsychology Exercise Aging Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial