2026-04-13T00:05:58Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1939472025-12-05T10:07:48Zcom_2072_1057col_2072_478916col_2072_478917col_2072_478929
RECERCAT author Jové, Mariona author Mota Martorell, Natàlia author Obis, Èlia author Sol, Joaquim author Martín Garí, Meritxell author Ferrer, Isidro (Ferrer Abizanda) author Portero-Otin, Manuel author Pamplona, Reinald 2023-02-23T16:27:17Z2023-02-23T16:27:17Z2023-01-122023-02-23T14:09:07Z It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. However, it is also evident that human neurons, although they are post-mitotic cells, survive throughout an entire lifetime. Therefore, to reduce or avoid the impact of oxidative stress on neuron functionality and survival, they must have evolved several adaptive mechanisms to cope with the deleterious effects of oxidative stress. Several of these antioxidant features are derived from lipid adaptations. At least six lipid adaptations against oxidative challenge in the healthy human brain can be discerned. In this work, we explore the idea that neurons and, by extension, the human brain is endowed with an important arsenal of non-pro-oxidant and antioxidant measures to preserve neuronal function, refuting part of the initial premise. cc by (c) Jové, Mariona et al., 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Colesterol Cervell Estrès oxidatiu Lípids Cholesterol Brain Oxidative stress Lipids Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion