2026-04-13T02:39:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1938602025-12-04T22:41:01Zcom_2072_1057col_2072_478825col_2072_478909col_2072_478917

00925njm 22002777a 4500 dc Guo, Longhua author Bloom, Joshua S. author Dols-Serrate, Daniel author Boocock, James author Ben David, Eyal author Schubert, Olga T. author Kozuma, Kaiya author Ho, Katarina author Warda, Emily author Chui, Clarice author Wei, Yubao author Leighton, Daniel author Lemus Vergara, Tzitziki author Riutort León, Marta author Sánchez Alvarado, Alejandro author Kruglyak, Leonid author 2023-02-20T08:40:57Z 2023-02-20T08:40:57Z 2022-06-01 2023-02-20T08:40:57Z The sexual strain of the planarian Schmidtea mediterranea, indigenous to Tunisia and several Mediterranean islands, is a hermaphrodite1,2 . Here we isolate individual chromosomes and use sequencing, Hi-C3,4 and linkage mapping to assemble a chromosome-scale genome reference. The linkage map reveals an extremely low rate of recombination on chromosome 1. We confrm suppression of recombination on chromosome 1 by genotyping individual sperm cells and oocytes. We show that previously identifed genomic regions that maintain heterozygosity even after prolonged inbreeding make up essentially all of chromosome 1. Genome sequencing of individuals isolated in the wild indicates that this phenomenon has evolved specifcally in populations from Sardinia and Corsica. We fnd that most known master regulators5-13 of the reproductive system are located on chromosome 1. We used RNA interference14,15 to knock down a gene with haplotype-biased expression, which led to the formation of a more pronounced female mating organ. On the basis of these observations, we propose that chromosome 1 is a sex-primed autosome primed for evolution into a sex chromosome Planària (Gènere) Genòmica Reproducció Planaria (Genus) Genomics Reproduction Island-specific evolution of a sex-primed autosome in a sexual planarian