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oai:recercat.cat:2445/1931812026-02-13T19:09:07Zcom_2072_1057col_2072_478858col_2072_478902col_2072_478917col_2072_478921

Long-term strenuous exercise promotes vascular injury by selectively damaging the tunica media: experimental evidence Rubies, Cira Batlle, Montserrat Sanz de la Garza, María Dantas, Ana Paula Jorba, Ignasi Fernàndez, Guerau Sangüesa Puigventós, Gemma Abuli, Marc Brugada Terradellas, Josep, 1958- Sitges Carreño, Marta Navajas Navarro, Daniel Mont Girbau, Lluís Guasch i Casany, Eduard Esports extrems Malalties vasculars Malalties coronàries Cèl·lules musculars Aterosclerosi Extreme sports Vascular diseases Coronary diseases Muscle cells Atherosclerosis Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise. 2023-02-06T19:09:09Z 2023-02-06T19:09:09Z 2022-07-13 2023-02-06T19:09:09Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2452-302X https://hdl.handle.net/2445/193181 722190 9328908 35958697 eng Reproducció del document de https://doi.org/10.1016/j.jacbts.2022.02.017 Jacc-Basic To Translational Science, 2022, vol. 7, num. 7, p. 681-693 https://doi.org/10.1016/j.jacbts.2022.02.017 cc by-nc-nd (c) Rubies, Cira et al., 2022 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess 13 p. application/pdf Articles publicats en revistes (Medicina)