2026-04-17T05:38:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1927922025-11-19T10:41:04Zcom_2072_1057col_2072_478782col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Espinoza, Lupe Carolina author Valarezo, Eduardo author Fábrega Fernández, María José author Rodríguez Lagunas, María José author Sosa Díaz, Lilian Elisa author Calpena Campmany, Ana Cristina author Mallandrich Miret, Mireia author 2023-01-30T10:50:10Z 2023-01-30T10:50:10Z 2022-11-15 2023-01-30T10:50:10Z Essential oils are natural aromatic substances that contain complex mixtures of many volatile compounds frequently used in pharmaceutical and cosmetic industries. Dacryodes peruviana (Loes.) H.J. Lam is a native species from Ecuador whose anti-inflammatory activity has not been previously reported, thus the aim of this study was to evaluate the anti-inflammatory activity of D. peruviana essential oil. To that end, essential oil from D. peruviana fruits was isolated by hydrodistillation and characterized physically and chemically. The tolerance of the essential oil was analyzed by cytotoxicity studies using human keratinocytes. The anti-inflammatory activity was evaluated by an arachidonic acid-induced edema model in mouse ear. The predominant compounds in D. peruviana essential oil were α-phellandrene, limonene, and α-pinene, with the three compounds reaching approximately 83% of the total composition. Tolerance studies showed high biocompatibility of this essential oil with human keratinocytes. In vivo studies demonstrated a moisturizing effect and an alleviation of several events occurred during the inflammatory process after topical treatment with D. peruviana essential oil such as decline in skin edema; reduction in leukocytic infiltrate; and decrease in inflammatory cytokines TNFα, IL-8, IL-17A, and IL-23. Therefore, this essential oil could be an attractive treatment for skin inflammation. Inflamació Olis essencials Llimones Inflammation Essences and essential oils Lemons Characterization and In Vivo Anti-Inflammatory Efficacy of Copal (Dacryodes peruviana (Loes.) H.J. Lam) Essential Oil