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oai:recercat.cat:2445/1922112025-12-04T21:12:52Zcom_2072_1057col_2072_478781col_2072_478917

Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Castro-Marrero, Jesús Domingo i Pedrol, Joan Carles Cordobilla, Begoña Ferrer, Roser Giralt, Marina Sanmartín-Sentañes, Ramon Alegre-Martín, José Sistema cardiovascular Coenzims Síndrome de fatiga crònica Inflamació Encefalomielitis Seleni Cardiovascular system Coenzymes Chronic fatigue syndrome Inflammation Encephalomyelitis Selenium Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neuroinflammatory, multifaceted chronic disorder of unknown cause. Accumulating data indicate a link between a redox imbalance, mitochondrial dys-function, and inflammation status in ME/CFS. Coenzyme Q10 (CoQ10) and selenium as effective antioxi-dant and anti-inflammatory agents have shown potential clinical implications in chronic diseases; however, their therapeutic benefits in ME/CFS remain elusive. This open-label exploratory study aimed to evaluate the effec- tiveness of combined CoQ10 plus selenium supplementation on clinical features and circulating biomarkers in ME/CFS. Twenty-seven ME/CFS patients received an oral combination of 400 mg of CoQ10 and 200 lg of selenium daily for 8 weeks. The primary endpoint was patient-reported changes in outcome measures from baseline to 8 weeks' postintervention. Secondary endpoint included changes in circulating biomarkers from base-line to each participant. After an 8-week intervention, a significant improvement was found for overall fatigue severity ( p = 0.021) and global quality of life ( p = 0.002), while there was no significant effect on the sleep dis-turbances ( p = 0.480) among participants. After 8 week's intervention, there was significantly increased total antioxidant capacity, and there were reduced lipoperoxide levels from the participants ( p < 0.0001 for both). Circulating cytokine levels decreased significantly ( p < 0.01 for all), but with no significant changes in the C-reactive protein, FGF21, and NT-proBNP biomarkers after supplementation. Based on these findings, we hypo-thesized that long-term supplementation of combined CoQ10 and selenium may indicate a potentially beneficial synergistic effect in ME/CFS. Antioxid. Redox Signal. 36, 729-739. 2023-01-17T10:02:54Z 2023-01-17T10:02:54Z 2022 2023-01-17T10:02:54Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1089/ars.2022.0018 Antioxidants & Redox Signaling, 2022, vol. 36, num. 10-12, p. 729-739 https://doi.org/10.1089/ars.2022.0018 cc by (c) Castro-Marrero, Jesús et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Mary Ann Liebert Articles publicats en revistes (Bioquímica i Biomedicina Molecular)