2026-04-17T06:13:48Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1922112025-12-04T21:12:52Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT author Castro-Marrero, Jesús author Domingo i Pedrol, Joan Carles author Cordobilla, Begoña author Ferrer, Roser author Giralt, Marina author Sanmartín-Sentañes, Ramon author Alegre-Martín, José 2023-01-17T10:02:54Z2023-01-17T10:02:54Z20222023-01-17T10:02:54Z Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neuroinflammatory, multifaceted chronic disorder of unknown cause. Accumulating data indicate a link between a redox imbalance, mitochondrial dys-function, and inflammation status in ME/CFS. Coenzyme Q10 (CoQ10) and selenium as effective antioxi-dant and anti-inflammatory agents have shown potential clinical implications in chronic diseases; however, their therapeutic benefits in ME/CFS remain elusive. This open-label exploratory study aimed to evaluate the effec- tiveness of combined CoQ10 plus selenium supplementation on clinical features and circulating biomarkers in ME/CFS. Twenty-seven ME/CFS patients received an oral combination of 400 mg of CoQ10 and 200 lg of selenium daily for 8 weeks. The primary endpoint was patient-reported changes in outcome measures from baseline to 8 weeks' postintervention. Secondary endpoint included changes in circulating biomarkers from base-line to each participant. After an 8-week intervention, a significant improvement was found for overall fatigue severity ( p = 0.021) and global quality of life ( p = 0.002), while there was no significant effect on the sleep dis-turbances ( p = 0.480) among participants. After 8 week's intervention, there was significantly increased total antioxidant capacity, and there were reduced lipoperoxide levels from the participants ( p < 0.0001 for both). Circulating cytokine levels decreased significantly ( p < 0.01 for all), but with no significant changes in the C-reactive protein, FGF21, and NT-proBNP biomarkers after supplementation. Based on these findings, we hypo-thesized that long-term supplementation of combined CoQ10 and selenium may indicate a potentially beneficial synergistic effect in ME/CFS. Antioxid. Redox Signal. 36, 729-739. cc by (c) Castro-Marrero, Jesús et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Sistema cardiovascular Coenzims Síndrome de fatiga crònica Inflamació Encefalomielitis Seleni Cardiovascular system Coenzymes Chronic fatigue syndrome Inflammation Encephalomyelitis Selenium Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion