2026-04-17T14:01:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1910732025-12-05T13:11:08Zcom_2072_1057col_2072_478798col_2072_478858col_2072_478916col_2072_478917

Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the prevention with mediterranean diet (PREDIMED) study Gutierrez Bedmar, Mario Martínez-González, Miguel Ángel, 1957- Muñoz Bravo, Carlos Ruiz Canela, Miguel Mariscal, Alberto Salas Salvadó, Jordi Estruch Riba, Ramon Corella Piquer, Dolores Aros, Fernando Fitó Colomer, Montserrat Lapetra, José Serra Majem, Lluís Pintó Sala, Xavier Alonso Gómez, Ángel M. Portoles, Olga Fiol Sala, Miguel Bulló, Mònica Castañer, Olga Ros Rahola, Emilio Gomez-Gracia, Enrique Malalties cardiovasculars Diabetis Dieta Cuina mediterrània Cardiovascular diseases Diabetes Diet Mediterranean cooking Background: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results: The associations between TCL and CVD were evaluated in a case-control study nested within the 'PREvencion con Dleta MEDiterranea' (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; P-trend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; P-trend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; P-trend=0.030) for the non-DM group (P for interaction=0.078).Conclusions: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD. 2022-11-22T17:56:24Z 2022-11-22T17:56:24Z 2017-08-01 2022-11-22T17:56:24Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1346-9843 https://hdl.handle.net/2445/191073 676975 28392547 eng Reproducció del document publicat a: https://doi.org/10.1253/circj.CJ-17-0032 Circulation Journal, 2017, vol. 81, num. 8, p. 1183-1190 https://doi.org/10.1253/circj.CJ-17-0032 (c) Japanese Circulation Society, 2017 info:eu-repo/semantics/openAccess 8 p. application/pdf Japanese Circulation Society Articles publicats en revistes (Ciències Clíniques)