2026-04-17T06:05:40Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1910102025-12-05T16:34:29Zcom_2072_1057col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Bermudo Gallaguet, Adrià author Ariza González, Mar author Dacosta-Aguayo, Rosalia author Agudelo, Daniela author Camins-Vila, Neus author Boldó, Maria author Carrera, Òscar author Vidal, Sandra author Ferrer-Uris, Blai author Busquets Faciabén, Albert author Via i García, Marc author Pera, Guillem author Cáceres, Cynthia author Gomis, Meritxell author García-Molina, Alberto author Tormos, José María author Arrabé, Ana author Diez, Gustavo author Durà Mata, Maria José author Torán Monserrat, Pere author Soriano Raya, Juan José author Domènech, Sira author Perera Lluna, Alexandre author Erickson, Kirk I. author Mataró Serrat, Maria author 2022-11-18T15:05:28Z 2022-11-18T15:05:28Z 2022-09-29 2022-11-18T15:05:28Z Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. Materials and methods: One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. Results: The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. Discussion: The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. Clinical trial registration: www.ClinicalTrials.gov, identifier NCT04759950. Embòlia i trombosi cerebral Malalties cerebrovasculars Teràpia cognitiva basada en l'atenció plena Exercici Marcadors bioquímics Cerebral embolism and thrombosis Cerebrovascular disease Mindfulness-based cognitive therapy Exercise Biochemical markers Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial