2026-04-17T10:51:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1893502025-12-05T13:04:04Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Vilchez, Helem H. author Escudero Sánchez, Rosa author Fernandez-Sampedro, Marta author Murillo Rubio, Óscar author Auñón, Álvaro author Rodríguez-Pardo, Dolors author Jover-Sáenz, Alfredo author Del Toro, Maria Dolores author Rico, Alicia author Falgueras, Luis author Praena Segovia, Julia author Guío, Laura author Iribarren, José A. author Lora-Tamayo Morillo-Velarde, Jaime author Benito Hernández, M. Natividad de author Morata, Laura author Ramirez, Antonio author Riera, Melchor author 2022-09-27T17:24:52Z 2022-09-27T17:24:52Z 2021-04-21 2022-09-27T17:24:52Z This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI. Bacteris anaerobis Infeccions Cirurgia Pròtesis Anaerobic bacteria Infections Surgery Prosthesis Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study.