2026-04-17T14:34:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1893502025-12-05T13:04:04Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

urn:hdl:2445/189350 Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study. Vilchez, Helem H. Escudero Sánchez, Rosa Fernandez-Sampedro, Marta Murillo Rubio, Óscar Auñón, Álvaro Rodríguez-Pardo, Dolors Jover-Sáenz, Alfredo Del Toro, Maria Dolores Rico, Alicia Falgueras, Luis Praena Segovia, Julia Guío, Laura Iribarren, José A. Lora-Tamayo Morillo-Velarde, Jaime Benito Hernández, M. Natividad de Morata, Laura Ramirez, Antonio Riera, Melchor Bacteris anaerobis Infeccions Cirurgia Pròtesis Anaerobic bacteria Infections Surgery Prosthesis This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI. 2022-09-27T17:24:52Z 2022-09-27T17:24:52Z 2021-04-21 2022-09-27T17:24:52Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10050475 Antibiotics, 2021, vol. 10, num. 5 https://doi.org/10.3390/antibiotics10050475 cc-by (c) Vilchez, Helem H. et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Ciències Clíniques)