2026-04-17T17:21:06Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/189202025-12-04T20:57:55Zcom_2072_1057col_2072_478796col_2072_478917
RECERCAT
author
Gomez, Jordi
author
Sagués i Mestre, Francesc
author
Reigada Sanz, Ramon
2011-07-07T12:55:24Z2011-07-07T12:55:24Z2008
Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and released. The model shows how cellular regulation of membrane cholesterol may determine the nanoscale lipid organization when the lipid mixture is close to a phase separation boundary, providing a plausible mechanism for raft formation in vivo.
(c) American Physical Society, 2008 info:eu-repo/semantics/openAccess
Biofísica
Física mèdica
Química física
Colesterol
Membranes cel·lulars
Biophysics
Medical physics
Physical chemistry
Cholesterol
Cell membranes
Actively maintained lipid nanodomains in biomembranes
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion