2026-04-13T04:13:27Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/189202025-12-04T20:57:55Zcom_2072_1057col_2072_478796col_2072_478917

00925njm 22002777a 4500 dc Gomez, Jordi author Sagués i Mestre, Francesc author Reigada Sanz, Ramon author 2011-07-07T12:55:24Z 2011-07-07T12:55:24Z 2008 Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and released. The model shows how cellular regulation of membrane cholesterol may determine the nanoscale lipid organization when the lipid mixture is close to a phase separation boundary, providing a plausible mechanism for raft formation in vivo. Biofísica Física mèdica Química física Colesterol Membranes cel·lulars Biophysics Medical physics Physical chemistry Cholesterol Cell membranes Actively maintained lipid nanodomains in biomembranes