2026-04-17T06:14:44Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1891862025-11-19T10:45:32Zcom_2072_1057col_2072_478902col_2072_478917
RECERCAT
author
Mesquida Veny, Francina
author
Martínez Torres, Sara
author
del Río, José Antonio
author
Hervera, Arnau
2022-09-20T09:38:40Z2022-09-20T09:38:40Z2022-08-172022-09-20T08:39:25Z
Abstract
Background
Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries.
Method
In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury.
Results
Opto- and chemogenetic stimulations of neuronal activity elicited increased in vitro neurite outgrowth in both sensory and cortical neurons, as well as in vivo regeneration in the sciatic nerve, but not after spinal cord injury. Mechanistically, inhibitory substrates such as chondroitin sulfate proteoglycans block the activity induced increase in axonal growth.
Conclusions
We found that genetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity but only on permissive environments.
cc by (c) Mesquida Veny, Francina et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
Axons
Lesions medul·lars
Axons
Spinal cord injuries
Genetic control of neuronal activity enhances axonal growth only on permissive substrates
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion