2026-04-13T07:36:11Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1886832025-12-05T14:18:13Zcom_2072_1057col_2072_478902col_2072_478917
RECERCAT
author
Garreta, Elena
author
Nauryzgaliyeva, Zarina
author
Montserrat Pulido, Núria
2022-09-05T08:07:02Z2022-09-05T08:07:02Z2021-12-012022-08-22T18:25:16Z
The generation of kidney organoids from human pluripotent stem cells (hPSCs) has represented a relevant scientific achievement in the organoid field. Importantly, hPSC-derived kidney organoids contain multiple nephron-like structures that exhibit some renal functional characteristics and have the capacity to respond to nephrotoxic agents. In this review, we first discuss how bioengineering approaches can help overcome current kidney organoid challenges. Next, we focus on recent works exploiting kidney organoids for drug screening and disease modeling applications. Finally, we provide a state of the art on current research toward the potential application of kidney organoids and renal cells derived from hPSCs for future renal replacement therapies.
cc by-nc-nd (c) Garreta, Elena et al., 2021 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
Enginyeria biomèdica
Ronyó
Cèl·lules mare
Biomedical engineering
Kidney
Stem cells
Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion