2026-04-17T12:02:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1886832025-12-05T14:18:13Zcom_2072_1057col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Garreta, Elena author Nauryzgaliyeva, Zarina author Montserrat Pulido, Núria author 2022-09-05T08:07:02Z 2022-09-05T08:07:02Z 2021-12-01 2022-08-22T18:25:16Z The generation of kidney organoids from human pluripotent stem cells (hPSCs) has represented a relevant scientific achievement in the organoid field. Importantly, hPSC-derived kidney organoids contain multiple nephron-like structures that exhibit some renal functional characteristics and have the capacity to respond to nephrotoxic agents. In this review, we first discuss how bioengineering approaches can help overcome current kidney organoid challenges. Next, we focus on recent works exploiting kidney organoids for drug screening and disease modeling applications. Finally, we provide a state of the art on current research toward the potential application of kidney organoids and renal cells derived from hPSCs for future renal replacement therapies. Enginyeria biomèdica Ronyó Cèl·lules mare Biomedical engineering Kidney Stem cells Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations