2026-04-17T04:26:35Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1870622026-01-31T11:07:29Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Santos Lasaosa, Sonia author Belvís, R. author Cuadrado, M. l. author Díaz Insa, S. author Gago Veiga, Ana Beatriz author Guerrero Peral, A. l. author Huerta, M. author Irimia, P. author Láinez, J.M. author Latorre, G. author Leira, R. author Pascual, J. author Porta-Etessam, Jesús author Sánchez del Río, M. author Viguera, J. author Pozo Rosich, Patricia author 2022-06-27T10:42:00Z 2022-06-27T10:42:00Z 2019-07-01 2022-06-27T09:54:56Z Introduction: It has been observed in recent years that levels of such molecules as calcitonin gene-related peptide (CGRP) and, to a lesser extent, the pituitary adenylate cyclase-activating peptide are elevated during migraine attacks and in chronic migraine, both in the cerebrospinal fluid and in the serum. Pharmacological reduction of these proteins is clinically significant, with an improvement in patients' migraines. It therefore seems logical that one of the main lines of migraine research should be based on the role of CGRP in the pathophysiology of this entity.Development: The Spanish Society of Neurology's Headache Study Group decided to draft this document in order to address the evidence on such important issues as the role of CGRP in the pathophysiology of migraine and the mechanism of action of monoclonal antibodies and gepants; and to critically analyse the results of different studies and the profile of patients eligible for treatment with monoclonal antibodies, and the impact in terms of pharmacoeconomics.Conclusions: The clinical development of gepants, which are CGRP antagonists, for the acute treatment of migraine attacks, and CGRP ligand and receptor monoclonal antibodies offer promising results for these patients. (c) 2019 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/). Calcitonina Migranya Calcitonin Migraine CGRP en migraña: de la fisiopatología a la terapéutica