2026-04-17T06:18:45Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1870562025-12-05T11:57:28Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT author Rokx, Casper author Lammers, Jolanda author Buitenhuis, Lonneke author Postma, Douwe author Koster, David author Lukens, Michaèl author Scholtens, Thea author Boomgaard, Maartje van den author Kampschreur, Linda author Ubals Cazorla, Maria author Prat, Núria author Soetekouw, Robert author Vall Mayans, Martí author Band, Caterina author Carceles Peiró, Victor author Gallardo, Mireia author Casares Gonzalez, Pablo author Galvan Femenia, Ivan author Comas Leon, Xavier author Millat Martínez, Pere author Bassat Orellana, Quique author Garcia, Nadia author González, María Isabel author Ancochea, Àgueda author Grífols, Joan Ramon author Verdaguer, Joaquim author Roquer López, Clàudia author Contreras, Enric author Giménez, Montserrat author Arcos Vila, Gemma author Ouchi, Dan author Blanco Guillermo, Ignacio author Vértiz Guidotti, Thatiana author Bonet Papell, Glòria author Dastis Arias, Macarena author Delgado Capel, Maria author Briones Zambrano, Ney Nicanor author Ferrer, Magí author Videla, Sebastià author Gudiol González, Carlota author Fernández Rivas, Gema author CoV-Early Study Group author García, Yolanda author Ruiz Comellas, Anna author Vonderen, Marit van author Bianco, Andrea Sofia author Bravo, Anna author Otero, Aurema author Millan, Anna author Ruibal Suarez, Jose Carlos author Benavent, Sergio author Zarauza Pellejero, Alvaro author Línio, Rosa author Malchair, Pierre author Baro, Bàrbara author Roca Font, Judit author Carrasco Matos, Katherine M. author Saüch Valmaña, Glòria author Vidal Obradors, Carla author Katsikis, Peter author Capdevila Jáuregui, Mar author Koopmans, Marion author Ara, Jordi author COnV-ert Study Group author Rodríguez Codina, Joana author Hernández, Luis author Tarres García, Silvia author Blanco, Ignacio author Hernández, Águeda author González Soler, Victoria author Curriu Sabatès, Margarida author Fornos, Miriam author Casamitjana, Natàlia author Bordoy, Antoni E. author Alonso, Eva author Groeneveld, Geert author Reusken, Chantal author Zwet, Erik van author Miedema, Jelle author Müller, Yvonne author Martinez, Núria author Ramírez Morros, Anna author Bogers, Susanne author Maglio, Laura Analía author Amado Simon, Rosa author Comellas Fernandez, Laura author Viozquez Meya, Maria author Costes, Gèlia author Pradenas Saavedra, Edwards author Forcada, Anna author Gammeren, Adriaan van author Ginneken, Betty van author Harvala, Heli author Zwaginga, Lisa author Marfil, Silvia author Troxel, Andrea author Mooijaart, Simon author Trinité, Benjamin author San José, Alba author Piccolo Ferreira, Francini author Bonet, Mireia author Blanco, Julian author Cantoni, Jordi author Russcher, Henk author Marks, Michael author Oud, Josine author Zwaginga, Jaap Jan author Torrano Soler, Pamela author Mitjà Villar, Oriol author Rijnders, Bart J. A. author Droog, José de author Ferrer, Susana author Alemany Ortiz, Andrea author Corbacho Monné, Marc author Scherpenisse, Cees author Hollander, Jan den author Gharbharan, Arvind author Meier, Romy author Rokx, Casper author Jordans, Carlijn author Geurtsvankessel, Corine author Albersen, Arjan author Papageourgiou, Grigorios author Puig, Jordi author Engen, Rene van author Karisli, Ayten author Götz, Hannelore author Struik, Jelle author Díez Sánchez, Beatriz author González Beiras, Camila author París, Alexa author Suñer Navarro, Clara author Clotet, Bonaventura, 1953- author Reimerink, Johan author Maas, Nanda author Rokx-Niemantsverdriet, Lotte author Rodriguez Arias, Miquel Angel author Jiménez, Zahida author Verstijnen, Jose author Geloven, Nan van author Swaneveld, Francis author Ramírez Viaplana, Ferran author Schoot, Ellen van der author Vrielink, Hans author Llopis Roca, Ferran author Gonzalez Ruiz, Cristian author Flores Aguilera, Begoña author Vivero Larraza, Ainhoa author Pons Barber, Maria author Watering, Leo van de author Hogema, Boris author González García, David author Wijngaarden, Peter van author Vidal Alaball, Josep author Etten, Ronald van author Berg – Rahman, Juliette van der author Karim, Faiz author Hiddema, Siepke author Elst, Kim van author Nieto Rodríguez, Raquel author García García, Vanesa author Casañ Lopez, Cristina author Rodriguez Cortez, Orlando author Leeuwen-Segarceanu, Elena van author Nieto, Aroa author Rodríguez Sevilla, Graciela author Reitsma, Annette author Navarrete Gonzalez, Laura author Molenkamp, Karin 2022-06-27T10:25:57Z2022-06-27T10:25:57Z2022-05-112022-06-23T11:35:25Z Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when <20% of recruitment target was achieved. A Bayesian-adaptive individual patient data metaanalysis was implemented. Outpatients aged >= 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution. cc by (c) Rokx, Casper et al, 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess COVID-19 Immunoregulació COVID-19 Immunoregulation Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion