2026-04-17T00:54:02Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1869602025-12-05T14:17:10Zcom_2072_1057col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Wagner, Anna M. author Eto, Hiromune author Joseph, Anton author Kohyama, Shunshi author Haraszti, Tamás author Zamora, Ricardo A. author Vorobii, Mariia author Giannotti, Marina Inés author Schwille, Petra author Rodriguez Emmenegger, César author 2022-06-23T06:24:43Z 2022-06-23T06:24:43Z 2022-06-06 2022-06-22T09:49:38Z The integration of active cell machinery with synthetic building blocks is the bridge toward developing synthetic cells with biological functions and beyond. Self-replication is one of the most important tasks of living systems, and various complex machineries exist to execute it. In Escherichia coli, a contractile division ring is positioned to mid-cell by concentration oscillations of self-organizing proteins (MinCDE), where it severs membrane and cell wall. So far, the reconstitution of any cell division machinery has exclusively been tied to liposomes. Here, the reconstitution of a rudimentary bacterial divisome in fully synthetic bicomponent dendrimersomes is shown. By tuning the membrane composition, the interaction of biological machinery with synthetic membranes can be tailored to reproduce its dynamic behavior. This constitutes an important breakthrough in the assembly of synthetic cells with biological elements, as tuning of membrane-divisome interactions is the key to engineering emergent biological behavior from the bottom-up. Biomimètica Fisiologia Biomimetics Physiology Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria