2026-04-14T06:11:35Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1865532025-12-05T14:18:17Zcom_2072_1057col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Lozano García, Manuel author Estrada Petrocelli, Luis author Blanco Almazan, Dolores author Tas, Basak author Cho, Peter S. P. author Moxham, John author Rafferty, Gerrard author Torres, Abel author Jane, Raimon author Jolley, C. J. author 2022-06-13T11:40:02Z 2022-06-13T11:40:02Z 2022-01-01 2022-06-13T10:07:34Z This study explored the use of parasternal second intercostal space and lower intercostal space surface electromyogram (sEMG) and surface mechanomyogram (sMMG) recordings (sEMGpara and sMMGpara, and sEMGlic and sMMGlic, respectively) to assess neural respiratory drive (NRD), neuromechanical (NMC) and neuroventilatory (NVC) coupling, and mechanical efficiency (MEff) noninvasively in healthy subjects and chronic obstructive pulmonary disease (COPD) patients. sEMGpara, sMMGpara, sEMGlic, sMMGlic, mouth pressure (Pmo), and volume (Vi) were measured at rest, and during an inspiratory loading protocol, in 16 COPD patients (8 moderate and 8 severe) and 9 healthy subjects. Myographic signals were analyzed using fixed sample entropy and normalized to their largest values (fSEsEMGpara%max, fSEsMMGpara%max, fSEsEMGlic%max, and fSEsMMGlic%max). fSEsMMGpara%max, fSEsEMGpara%max, and fSEsEMGlic%max were significantly higher in COPD than in healthy participants at rest. Parasternal intercostal muscle NMC was significantly higher in healthy than in COPD participants at rest, but not during threshold loading. Pmo-derived NMC and MEff ratios were lower in severe patients than in mild patients or healthy subjects during threshold loading, but differences were not consistently significant. During resting breathing and threshold loading, Vi-derived NVC and MEff ratios were significantly lower in severe patients than in mild patients or healthy subjects. sMMG is a potential noninvasive alternative to sEMG for assessing NRD in COPD. The ratios of Pmo and Vi to sMMG and sEMG measurements provide wholly noninvasive NMC, NVC, and MEff indices that are sensitive to impaired respiratory mechanics in COPD and are therefore of potential value to assess disease severity in clinical practice. Author Malalties pulmonars obstructives cròniques Respiració artificial Chronic obstructive pulmonary diseases Artificial respiration Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD