2026-04-13T01:26:07Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/186542025-12-05T16:28:18Zcom_2072_1057col_2072_478917col_2072_478921
RECERCAT author Bellis, L. author Moitinho, E. author Abraldes, Juan G. author Graupera i Garcia-Milà, Mariona author García Pagán, Juan Carlos author Rodés, J. author Bosch i Genover, Jaume 2011-07-07T12:30:27Z2011-07-07T12:30:27Z2003 Background and aims: Up to 60% of patients treated with transjugular intrahepatic portosystemic shunt (TIPS) require angioplasty or restenting during the first year of follow up because of TIPS dysfunction (stenosis of the intrahepatic shunt increasing the portal pressure gradient above the 12 mm Hg threshold). We hypothesised that in patients with TIPS stenosis, propranolol administration, by decreasing portal inflow, would markedly decrease portal pressure. Patients and methods: Eighteen patients with TIPS dysfunction were investigated by measuring portal pressure gradient before and after acute propranolol administration (0.2 mg/kg intravenously; n=18). Results: Propranolol markedly reduced the portal pressure gradient (from 16.6 (3.5) to 11.9 (4.8) mm Hg; p<0.0001), cardiac index (−26 (7)%), and heart rate (−18 (7)%) (p<0.0001). Portal pressure gradient decreased to less than 12 mm Hg in nine patients, more frequently in those with moderate dysfunction (portal pressure gradient 16 mm Hg) than in patients with severe dysfunction (portal pressure gradient >16 mm Hg) (8/10 v 1/8; p=0.015). Conclusions: Propranolol therapy may delay the increase in portal pressure and reduce the need for reintervention in patients with TIPS dysfunction. (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2003 info:eu-repo/semantics/openAccess Hipertensió portal Beta-blocadors Pressió venosa Portal hypertension Adrenergic beta blockers Venous pressure Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Transjugular intrahepatic portosystemic shunt info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion