2026-04-17T20:13:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1862502025-12-05T12:42:20Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Bailén, Rebeca author Pascual Cascón, María Jesús author Guerreiro, Manuel author López Corral, Lucía author Chinea, Anabelle author Bermúdez, Arancha author Sampol, Antonia author Heras, Inmaculada author García Torres, Estefanía author Torres, Melissa author Rifón Roca, José author Herruzo, Beatriz author Sanz, Jaime author Fonseca, Marta author Herrera, Pilar author Colorado, Mercedes author Bento, Leyre author López Godino, Oriana author Martín Calvo, Carmen author Fernández Caldas, Paula author Marcos Jubilar, María author Sánchez Ortega, Isabel author Solano, Carlos author Noriega, Víctor author Humala, Karem author Oarbeascoa, Gillen author Díez Martín, José Luis author Kwon, Mi author 2022-06-02T08:55:29Z 2022-06-02T08:55:29Z 2022-01-01 2022-06-02T07:41:39Z Post-transplantation cyclophosphamide (PTCY) effectively prevents graft-versus-host disease (GVHD) after unmanipulated HLA-haploidentical hematopoietic stem cell transplantation (HSCT) and achieves low rates of GVHD in HLA-identical transplantation. To compare the outcomes of haploidentical versus HLA identical HSCT in patients undergoing HSCT for acute myeloid leukemia (AML) using PTCY. We conducted a retrospective study of 229 patients undergoing first HSCT for AML using PTCY with additional immunosuppression, 99 from matched sibling or unrelated donor (MSD/MUD) performed in 3 hospitals and 130 from haploidentical donors (haplo group) performed in 20 hospitals within the Spanish Group of Hematopoietic Stem Cell Transplantation and Cellular Therapy. Peripheral blood stem cells were used as graft in 89% of patients; myeloablative conditioning was used in 56%. There were significantly more patients with active disease (5% versus 20%, P = .001), high/very high disease risk index (DRI) (32% versus 67%, P = .000) and prior auto-HSCT (2% versus 11%, P = .010) in the haplo group. Median follow-up was 27 and 62.5 months for MSD/MUD and haplo, respectively. At 2 years, no significant differences were observed in overall survival (OS) (72% versus 62%, P = .07), event-free survival (EFS) (70% versus 54%, P = .055), cumulative incidence of relapse (19% versus 25%, P = .13), non-relapse mortality (14% versus 19%, P = .145), and the composite endpoint of GVHD and relapse-free survival (49% versus 42%, P = .249). Multivariate analysis identified only age and active disease as significant risk factors for OS and EFS; reduced-intensity conditioning, high/very high DRI, and haplo donor were nearly statistically significant for these outcomes. Grade II-IV acute GVHD was lower in MSD/MUD (14% versus 47%, P = .000). Cumulative incidences of grade III-IV acute GVHD (4% versus 9%, P = .14) and moderate-severe chronic GVHD (22% versus 19%, P = .28) were similar. Limitations of our study include limited sample size, differences between haplo and MSD/MUD groups and heterogeneous additional immunosuppression and PTCY timing in MSD/MUD. The use of an HLA-identical donor with PTCY in patients with AML showed lower incidence of clinically significant grade II-IV acute GVHD compared to haplo donors. Further studies with larger sample sizes should be performed to establish a possible benefit of HLA-identical donor on survival. (C) 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. Leucèmia mieloide Trasplantament d'òrgans Myeloid leukemia Transplantation of organs Post-transplant cyclophosphamide after HLA identical compared to Haploidentical donor transplant in Acute Myeloid Leukemia: a study on behalf of GETH-TC