2026-04-19T18:51:54Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1851832025-12-04T21:44:03Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Palmeira-Mello, Marcos V.
author
Caballero Hernández, Ana Belén
author
López Espinar, Aida
author
Guedes, Guilherme P.
author
Caubet Marín, Amparo
author
Teles de Souza, Alessandra M.
author
Lanznaster, Mauricio
author
Gámez Enamorado, Patrick
2022-04-26T16:41:25Z2022-04-26T16:41:25Z20212022-04-26T16:41:25Z
Two square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies revealed that the two isostructural compounds were interacting differently with DNA. In both cases, the initial interaction involves electrostatic contacts of the CPYA ligand in the minor groove (as suggested by molecular docking), but subsequent strong binding occurs with the palladium(II) complex 2, whereas the binding with the copper complex 1 is weaker and concentration dependent. The strong binding of 2 eventually leads to the cleavage of the double strand and the redox activity of 1 allows to oxidatively cleave the biomolecule.
cc-by (c) Palmeira-Mello, Marcos V., et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
ADN
Cisplatí
Pal·ladi (Element químic)
DNA
Cisplatin
Palladium
DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion