2026-04-19T20:37:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1851832025-12-04T21:44:03Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Palmeira-Mello, Marcos V. author Caballero Hernández, Ana Belén author López Espinar, Aida author Guedes, Guilherme P. author Caubet Marín, Amparo author Teles de Souza, Alessandra M. author Lanznaster, Mauricio author Gámez Enamorado, Patrick author 2022-04-26T16:41:25Z 2022-04-26T16:41:25Z 2021 2022-04-26T16:41:25Z Two square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies revealed that the two isostructural compounds were interacting differently with DNA. In both cases, the initial interaction involves electrostatic contacts of the CPYA ligand in the minor groove (as suggested by molecular docking), but subsequent strong binding occurs with the palladium(II) complex 2, whereas the binding with the copper complex 1 is weaker and concentration dependent. The strong binding of 2 eventually leads to the cleavage of the double strand and the redox activity of 1 allows to oxidatively cleave the biomolecule. ADN Cisplatí Pal·ladi (Element químic) DNA Cisplatin Palladium DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium