2026-04-17T03:45:31Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1849572025-12-05T14:54:40Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Lefèvre Arbogast, Sophie author Hejblum, Boris P. author Helmer, Catherine author Klose, Christian author Manach, Claudine author Low, Dorrain Yanwen author Urpí Sardà, Mireia author Andrés Lacueva, Ma. Cristina author González-Domínguez, Raúl author Aigner, Ludwig author Altendorfer, Barbara author Lucassen, Paul J. author Ruigrok, Silvie R. author de Lucia, Chiara author Du Preez, Andrea author Proust Lima, Cécile author Thuret, Sandrine author Korosi, Aniko author Samieri, Cécilia author 2022-04-14T08:21:51Z 2022-04-14T08:21:51Z 2021-01-25 2022-04-14T08:21:51Z Background Brain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to cognitive decline remains unclear at the system level. Methods We studied participants from the Three-City study, a multicentric cohort of older persons, free of dementia at time of blood sampling, and who provided repeated measures of cognition over 12 subsequent years. We measured 189 serum lipids from 13 lipid classes using shotgun lipidomics in a case-control sample on cognitive decline (matched on age, sex and level of education) nested within the Bordeaux study center (discovery, n = 418). Associations with cognitive decline were investigated using bootstrapped penalized regression, and tested for validation in the Dijon study center (validation, n = 314). Findings Among 17 lipids identified in the discovery stage, lower levels of the triglyceride TAG50:5, and of four membrane lipids (sphingomyelin SM40:2,2, phosphatidylethanolamine PE38:5(18:1/20:4), ether-phosphatidylethanolamine PEO34:3(16:1/18:2), and ether-phosphatidylcholine PCO34:1(16:1/18:0)), and higher levels of PCO32:0(16:0/16:0), were associated with greater odds of cognitive decline, and replicated in our validation sample. Interpretation These findings indicate that in the blood lipidome of non-demented older persons, a specific profile of lipids involved in membrane fluidity, myelination, and lipid rafts, is associated with subsequent cognitive decline. Funding The complete list of funders is available at the end of the manuscript, in the Acknowledgement section. Metabòlits Dieta Demència Metabolites Diet Dementia Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study