2026-04-17T05:18:04Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1847722025-12-04T20:48:03Zcom_2072_1057col_2072_478822col_2072_478914col_2072_478917
RECERCAT
author
Guha, Sougata
author
Mitra, Mithun K.
author
Pagonabarraga Mora, Ignacio
author
Muhuri, Sudipto
2022-04-06T13:39:42Z2022-04-06T13:39:42Z2021-04-012022-04-06T13:39:42Z
Generation of mechanical oscillations is ubiquitous to a wide variety of intracellular processes, ranging from activity of muscle fibers to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and generating spontaneous oscillations. Although the structural features and properties of the individual motors are well characterized, their implications on the functional behavior of motor-filament complexes are more involved. We show that force-induced allosteric deformations in dynein, which result in catchbonding behavior, provide a generic mechanism to generate spontaneous oscillations in motor-cytoskeletal filament complexes. The resultant phase diagram of such motor-filament systems¿characterized by force-induced allosteric deformations¿exhibits bistability and sustained limit-cycle oscillations in biologically relevant regimes, such as for catchbonded dynein. The results reported here elucidate the central role of this mechanism in fashioning a distinctive stability behavior and oscillations in motor-filament complexes such as mitotic spindles.
cc-by-nc-nd (c) Biophysical Society, 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Oscil·lacions
Citosquelet
Microtúbuls
Oscillations
Cytoskeleton
Microtubules
Novel mechanism for oscillations in catchbonded motor-filament complexes
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion