2026-04-17T05:38:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1847722025-12-04T20:48:03Zcom_2072_1057col_2072_478822col_2072_478914col_2072_478917

00925njm 22002777a 4500 dc Guha, Sougata author Mitra, Mithun K. author Pagonabarraga Mora, Ignacio author Muhuri, Sudipto author 2022-04-06T13:39:42Z 2022-04-06T13:39:42Z 2021-04-01 2022-04-06T13:39:42Z Generation of mechanical oscillations is ubiquitous to a wide variety of intracellular processes, ranging from activity of muscle fibers to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and generating spontaneous oscillations. Although the structural features and properties of the individual motors are well characterized, their implications on the functional behavior of motor-filament complexes are more involved. We show that force-induced allosteric deformations in dynein, which result in catchbonding behavior, provide a generic mechanism to generate spontaneous oscillations in motor-cytoskeletal filament complexes. The resultant phase diagram of such motor-filament systems¿characterized by force-induced allosteric deformations¿exhibits bistability and sustained limit-cycle oscillations in biologically relevant regimes, such as for catchbonded dynein. The results reported here elucidate the central role of this mechanism in fashioning a distinctive stability behavior and oscillations in motor-filament complexes such as mitotic spindles. Oscil·lacions Citosquelet Microtúbuls Oscillations Cytoskeleton Microtubules Novel mechanism for oscillations in catchbonded motor-filament complexes