2026-04-17T21:40:10Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1839502025-12-05T14:54:17Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Aledavood, Elnaz author Selmi, Beatrice author Estarellas, Carolina author Masetti, Matteo author Luque Garriga, F. Xavier author 2022-03-10T10:11:46Z 2022-03-10T10:11:46Z 2022-01-14 2022-03-10T10:11:48Z With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains. Influenzavirus Química orgànica Virus Influenza viruses Organic chemistry Viruses From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus