2026-04-13T13:45:42Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1839462025-12-05T14:12:15Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Cano Fernández, Amanda author Fonseca, Elena author Ettcheto Arriola, Miren author Sánchez-López, E. (Elena) author Rojas, Itziar de author Alonso Lana, Silvia author Morató Arús, Xavier author Souto, Eliana B. author Toledo, Manuel author Boada, Mercè author Marquié, Marta author Ruiz, Agustín author 2022-03-10T06:37:21Z 2022-03-10T06:37:21Z 2021 2022-03-10T06:37:21Z Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects that lead to cell death focuses on the exacerbation of the glutamate pathway and the massive influx of Ca2+ into neurons by different factors. However, other mechanisms have been proposed, and most of them have also been described in other neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or multiple sclerosis. Interestingly, and mainly because of these common molecular links and the lack of effective treatments for these diseases, some antiseizure drugs have been investigated to evaluate their therapeutic potential in these pathologies. Therefore, in this review, we thoroughly investigate the common molecular pathways between epilepsy and the major neurodegenerative diseases, examine the incidence of epilepsy in these populations, and explore the use of current and innovative antiseizure drugs in the treatment of refractory epilepsy and other neurodegenerative diseases. Keywords: Alzheimer's disease; Huntington's disease; Parkinson's disease; epilepsy; multiple sclerosis; neurodegenerative diseases. Malalties neurodegeneratives Malaltia d'Alzheimer Malaltia de Parkinson Neurodegenerative Diseases Alzheimer's disease Parkinson's disease Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways