2026-04-17T05:47:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1838792025-12-05T13:14:14Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Bonanad, Clara author García Blas, Sergio author Torres Llergo, Javier author Fernández Olmo, Rosa author Díez Villanueva, Pablo author Ariza Solé, Albert author Martínez Sellés, Manuel author Raposeiras Roubín, Sergio author Ayesta, Ana author Bertomeu González, Vicente author Tarazona Santabalbina, Francisco author Facila, Lorenzo author Vivas, David author Gabaldón Pérez, Ana author Bodi, Vicente author Nuñez, Julio author Cordero, Alberto author 2022-03-08T07:42:33Z 2022-03-08T07:42:33Z 2021-11-12 2022-03-08T07:42:34Z Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Primary endpoints were stroke or systemic embolism and all-cause death. Secondary endpoints included major bleeding, intracranial bleeding, and gastrointestinal bleeding. A random-effects model was selected due to significant heterogeneity. A total of 147,067 patients from 16 studies were included, 71,913 (48.90%) treated with DOACs and 75,154 with VKA (51.10%). The stroke rate was significantly lower in DOACs group compared with warfarin group (Relative risk (RR): 0.72; 95% confidence interval (CI): 0.63-0.82; p < 0.001). All-cause mortality was significantly lower in DOACs group compared with warfarin group (RR: 0.82; 95% CI: 0.70-0.96; p = 0.012). Compared to warfarin, DOACs were not associated with reductions in major bleeding (RR: 0.85, 95% CI 0.69-1.04; p = 0.108) or gastrointestinal bleeding risk (RR: 1.08, 95% CI 0.76-1.53; p = 0.678) but a 43% reduction of intracranial bleeding (RR: 0.47, IC 95% 0.36-0.60; p < 0.001) was observed. Our meta-analysis demonstrates that DOACs are effective and safe with statistical superiority when compared with warfarin in octogenarians with AF. Persones grans Malalties coronàries Anticoagulants (Medicina) Infart de miocardi Older people Coronary diseases Anticoagulants (Medicine) Myocardial infarction Direct Oral Anticoagulants versus Warfarin in Octogenarians with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis