2026-04-13T12:22:35Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1835222025-12-04T19:31:55Zcom_2072_1057col_2072_478908col_2072_478917
RECERCAT
author
Calon, Alexandre
author
Espinet, Elisa
author
Palomo Ponce, Sergio
author
Tauriello, Daniele V. F.
author
Iglesias, Mar
author
Céspedes, María
author
Sevillano, Marta
author
Nadal, Cristina
author
Jung, Peter
author
Zhang, Xiang
author
Byrom, Daniel
author
Riera i Escalé, Antoni
author
Rossell, David
author
Mangues, Ramon
author
Massagué i Solé, Joan, 1953-
author
Sancho, Elena
author
Batlle, Eduard
2022-02-24T19:00:17Z2022-02-24T19:00:17Z2014-05-052022-02-24T12:05:08Z
Metastasis depends on a gene program expressed by the tumor microenvironment
upon TGF-beta stimulation. CRC (Colorectal cancer) cell lines did not induce robust stromal TGF-
beta responses when injected into nude mice as shown by lack of p- SMAD2 accumulation in
tumor-associated stromal cells. To enforce high TGF-beta signaling in xenografts, we engineered
CRC cell lines to secrete active TGF-beta. Subcutaneous tumors obtained from HT29-M6TGF-β,
KM12L4aTGF-β cells and SW48TGF-β cells contained abundant p-SMAD2+ stromal cells.
(c) Bio-protocol LLC, 2014 info:eu-repo/semantics/openAccess
Càncer colorectal
Metàstasi
Expressió gènica
Colorectal cancer
Metastasis
Gene expression
Immunostaining Protocol: P-Smad2 (Xenograft and Mice)
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion